Cook Alex Biotechnology & Pharmaceutical Representative Publications

Biotechnology & Pharmaceutical Practice Group

Representative Publications

Shumaker DK, Lopez-Soler RI, Adams SA, Herrmann H, Moir RD, Spann TP, Goldman RD (2005). Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A. 102 (43):15494-15499.
Spann TP, Goldman AE, Wang C, Huang S, Goldman RD (2002). Alteration of lamin organization inhibits RNA polymerase II dependent transcription. J. Cell Biol. 156:605-608.
Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP (2002). Nuclear lamins: building blocks of nuclear architecture. Genes Dev. 16 (5):533-547.
Lopez-Soler RI, Moir RD, Spann TP, Stick R, Goldman RD (2001). A role for nuclear lamins in nuclear envelope assembly. J Cell Biol.. 154(1):61-70.
de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC (2001). Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 294(5544):1105-1108.
Moir RD, Spann TP (2001). The structure and function of nuclear lamins: implications for disease. CMLS. 58:1748-1757.
Yoon KH, Yoon M, Moir RD, Khuon S, Flitney FW, Goldman RD (2001). Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells. J Cell Biol. 153(3):503-516.
Moir RD, Yoon M, Khuon S, Goldman RD (2000). Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells. J Cell Biol. 151(6):1155-1168.
Moir RD, Spann TP, Herrmann H, Goldman RD (2000). Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J. Cell Biol. 149(6):1179-1192.
Moir RD, Spann TP, Goldman RD (1999). The Nuclear Lamins: Type V intermediate filament proteins. A Guidebook to the Cytoskeleton (editors, Vale and Kreis). Oxford University Press. Second Edition, p. 324-326.
Prahlad V, Yoon M, Moir RD, Vale RD, Goldman RD (1998). Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks. J Cell Biol. 143(1):159-170.
Yoon M, Moir RD, Prahlad V, Goldman RD (1998). Motile properties of vimentin intermediate filament networks in living cells. J Cell Biol. 143(1):147-157.
Spann TP, Moir RD, Goldman AE, Stick R, Goldman RD (1997). Disruption of the nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. J. Cell Biol. 136(6):1201-1212.
Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC (1996). Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A. 93(16):8395-8340.
Spann TP, Brock DA, Lindsey DF, Wood SA, Gomer RH (1996). Mutagenesis and gene identification in Dictyostelium by shotgun antisense. Proc Natl Acad Sci U.S.A. 93 (10):5003-5007.
Wood SA, Ammann RR, Brock DA, Li L. Spann TP, Gomer RH (1996). RtoA links initial cell type choice to the cell cycle in Dictyostelium. Development 122 (11):3677-3685.
Brock DA, Buczyndki G, Spann TP, Wood SA, Cardelli J, Gomer, RH (1996). A Dictyostelium mutant with defective aggregate size determination. Development. 122 (9): 2569-2578.
Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC (1995). Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U.S.A. 92(20):9042-9046.
Moir RD, Montag-Lowy M, Goldman RD (1994). Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication. J Cell Biol. 125(6):1201-1212.
Goldman AE, Moir RD, Montag-Lowy M, Stewart M, Goldman RD (1992). Pathway of incorporation of microinjected lamin A into the nuclear envelope. J Cell Biol. 119(4):725-735.
Moir RD, Donaldson AD, Stewart M (1991). Expression in Escherichia coli of human lamins A and C: influence of head and tail domains on assembly properties and paracrystal formation. J Cell Sci. 99 ( Pt 2):363-372.
Stewart M, Quinlan RA, Moir RD (1989). Molecular interactions in paracrystals of a fragment corresponding to the alpha-helical coiled-coil rod portion of glial fibrillary acidic protein: evidence for an antiparallel packing of molecules and polymorphism related to intermediate filament structure. J Cell Biol. 109(1):225-234.
Quinlan RA, Moir RD, Stewart M (1989). Expression in Escherichia coli of fragments of glial fibrillary acidic protein: characterization, assembly properties and paracrystal formation. J Cell Sci. 93( Pt 1):71-83.
Winkfein RJ, Moir RD, Krawetz SA, Blanco J, States JC, Dixon GH (1988). A new family of repetitive, retroposon-like sequences in the genome of the rainbow trout. Eur. J. Biochem. 176(2):255-264.
Newport J, Spann TP (1987). Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes. Cell 48: 219-230.


Biotechnology & Pharmaceutical Practice Group Chemical Practice Group Computers, Electronics & Software Practice Group Industrial & Mechanical Practice Group Medical Devices Practice Group	Biotechnology & Pharmaceutical Practice Group Representative Publications Shumaker DK, Lopez-Soler RI, Adams SA, Herrmann H, Moir RD, Spann TP, Goldman RD (2005). Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A. 102 (43):15494-15499. Spann TP, Goldman AE, Wang C, Huang S, Goldman RD (2002). Alteration of lamin organization inhibits RNA polymerase II dependent transcription. J. Cell Biol. 156:605-608. Goldman RD, Gruenbaum Y, Moir RD, Shumaker DK, Spann TP (2002). Nuclear lamins: building blocks of nuclear architecture. Genes Dev. 16 (5):533-547. Lopez-Soler RI, Moir RD, Spann TP, Stick R, Goldman RD (2001). A role for nuclear lamins in nuclear envelope assembly. J Cell Biol.. 154(1):61-70. de Noronha CM, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC (2001). Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science. 294(5544):1105-1108. Moir RD, Spann TP (2001). The structure and function of nuclear lamins: implications for disease. CMLS. 58:1748-1757. Yoon KH, Yoon M, Moir RD, Khuon S, Flitney FW, Goldman RD (2001). Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells. J Cell Biol. 153(3):503-516. Moir RD, Yoon M, Khuon S, Goldman RD (2000). Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells. J Cell Biol. 151(6):1155-1168. Moir RD, Spann TP, Herrmann H, Goldman RD (2000). Disruption of nuclear lamin organization blocks the elongation phase of DNA replication. J. Cell Biol. 149(6):1179-1192. Moir RD, Spann TP, Goldman RD (1999). The Nuclear Lamins: Type V intermediate filament proteins. A Guidebook to the Cytoskeleton (editors, Vale and Kreis). Oxford University Press. Second Edition, p. 324-326. Prahlad V, Yoon M, Moir RD, Vale RD, Goldman RD (1998). Rapid movements of vimentin on microtubule tracks: kinesin-dependent assembly of intermediate filament networks. J Cell Biol. 143(1):159-170. Yoon M, Moir RD, Prahlad V, Goldman RD (1998). Motile properties of vimentin intermediate filament networks in living cells. J Cell Biol. 143(1):147-157. Spann TP, Moir RD, Goldman AE, Stick R, Goldman RD (1997). Disruption of the nuclear lamin organization alters the distribution of replication factors and inhibits DNA synthesis. J. Cell Biol. 136(6):1201-1212. Takahashi A, Alnemri ES, Lazebnik YA, Fernandes-Alnemri T, Litwack G, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC (1996). Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A. 93(16):8395-8340. Spann TP, Brock DA, Lindsey DF, Wood SA, Gomer RH (1996). Mutagenesis and gene identification in Dictyostelium by shotgun antisense. Proc Natl Acad Sci U.S.A. 93 (10):5003-5007. Wood SA, Ammann RR, Brock DA, Li L. Spann TP, Gomer RH (1996). RtoA links initial cell type choice to the cell cycle in Dictyostelium. Development 122 (11):3677-3685. Brock DA, Buczyndki G, Spann TP, Wood SA, Cardelli J, Gomer, RH (1996). A Dictyostelium mutant with defective aggregate size determination. Development. 122 (9): 2569-2578. Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC (1995). Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U.S.A. 92(20):9042-9046. Moir RD, Montag-Lowy M, Goldman RD (1994). Dynamic properties of nuclear lamins: lamin B is associated with sites of DNA replication. J Cell Biol. 125(6):1201-1212. Goldman AE, Moir RD, Montag-Lowy M, Stewart M, Goldman RD (1992). Pathway of incorporation of microinjected lamin A into the nuclear envelope. J Cell Biol. 119(4):725-735. Moir RD, Donaldson AD, Stewart M (1991). Expression in Escherichia coli of human lamins A and C: influence of head and tail domains on assembly properties and paracrystal formation. J Cell Sci. 99 ( Pt 2):363-372. Stewart M, Quinlan RA, Moir RD (1989). Molecular interactions in paracrystals of a fragment corresponding to the alpha-helical coiled-coil rod portion of glial fibrillary acidic protein: evidence for an antiparallel packing of molecules and polymorphism related to intermediate filament structure. J Cell Biol. 109(1):225-234. Quinlan RA, Moir RD, Stewart M (1989). Expression in Escherichia coli of fragments of glial fibrillary acidic protein: characterization, assembly properties and paracrystal formation. J Cell Sci. 93( Pt 1):71-83. Winkfein RJ, Moir RD, Krawetz SA, Blanco J, States JC, Dixon GH (1988). A new family of repetitive, retroposon-like sequences in the genome of the rainbow trout. Eur. J. Biochem. 176(2):255-264. Newport J, Spann TP (1987). Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes. Cell 48: 219-230.	Representative Patents Representative Clients Representative Publications John L. Alex Betsy J. Derwinski Joseph T. Harcarik Steven E. Jedlinski Andrew G. Kolomayets Gary W. McFarron Raymond M. Mehler Robert D. Moir, Ph.D. Mark J. Murphy Timothy P. Spann, Ph.D. Michael D. Zaronias